Suppressed virulence and enhanced antibiotic efficacy of madecassic acid as a potent quorum sensing inhibitor against Klebsiella pneumoniae

Key Points

• Suppressed virulence observed in Klebsiella pneumoniae with madecassic acid treatment, improving outcomes.
• Treatment with madecassic acid led to a notable increase in antibiotic effectiveness against this pathogen.
• The observational analysis focused on the roles of quorum sensing and madecassic acid in modulating virulence.
• These findings suggest a promising application of madecassic acid in combating antibiotic resistance in pathogens.