Tapentadol induces progressive hepatic damage via disrupting Hippo–YAP and bile acid–FXR pathways: An integrated experimental and computational perspective | Synapse
March 3, 2026
Tapentadol induces progressive hepatic damage via disrupting Hippo–YAP and bile acid–FXR pathways: An integrated experimental and computational perspective
Key Points
Hepatic damage progresses due to disruptions in hippo and yap pathways caused by tapentadol, which is critical for liver health.
Key findings indicate significant dysregulation in bile acid metabolism when exposed to tapentadol.
Integrated experimental and computational methods reveal complex interactions within molecular pathways affected by tapentadol.
Further investigation is needed to assess long-term implications of tapentadol use on liver function and overall health.