pH and thermal dual sensitive injectable microgels loaded with doxorubicin for the localized neoadjuvant chemotherapy of breast cancer

Key Points

• Localized neoadjuvant chemotherapy significantly enhances drug delivery efficiency in breast cancer.
• The dual-sensitive microgels release doxorubicin in response to specific pH levels and temperature changes.
• Assessment using pH and thermal dual-sensitive injectable microgels demonstrates their potential in targeting tumor sites effectively.
• This approach may improve treatment outcomes, but clinical translation requires further investigation.