Fasting-mimicking diet induces IFNβ secretion in tumor-associated macrophages via NRF1-mediated ubiquitin-dependent proteolysis of Trex1

Key Points

• Fasting-mimicking diet triggers significant Ifnβ secretion in tumor-associated macrophages, boosting immune response.
• The study reports that NRF1 plays a critical role in mediating ubiquitin-dependent proteolysis of Trex1.
• Observational analysis demonstrates the impact of nutrition on macrophage function and tumor biology.
• The findings highlight the potential of dietary interventions in enhancing immune effectiveness against tumors.