Sevoflurane, but not alphaxalone, causes lasting autism spectrum disorder-like pathology in male mice after exposure occurs during synaptogenesis

Key Points

• Lasting autism spectrum disorder-like pathology is observed in male mice exposed to sevoflurane.
• The pathology develops following exposure during the critical period of synaptogenesis in the developing brain.
• Assessment involved comparing the effects of sevoflurane and alphaxalone on male mice with regard to autism-related behaviors.
• These findings indicate potential long-term risks associated with sevoflurane and stress the need for caution in clinical settings.