Targeting store-operated Ca2+ entry as a novel strategy to overcome treatment resistance in melanoma

Key Points

• Treatment resistance in melanoma may be alleviated through the manipulation of store-operated calcium entry.
• Key evidence indicates that targeting this calcium pathway can significantly enhance responsiveness to therapies.
• Analysis employs a biochemical approach to understand calcium signaling mechanisms in melanoma cells.
• Findings highlight the need for further exploration of calcium modulation strategies for effective melanoma therapies.