Mechano responsiveness of neuroimmune cross-talk in bone and joints: A narrative review with implications for force-based manipulations

Key Points

• Neuroimmune cross-talk may influence how bones and joints respond to mechanical forces, suggesting a critical interaction at play.
• The review discusses various mechanisms and potential implications of using force-based manipulations on these systems to enhance healing.
• Observational analysis of existing literature reveals a strong connection between mechanical stimuli and neuroimmune responses in musculoskeletal health.
• These findings support the idea that targeted interventions could optimize therapeutic approaches for bone and joint conditions.