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Altered tryptophan metabolism and the role of the kynurenine pathway in multiple system atrophy | Synapse
March 3, 2026
Altered tryptophan metabolism and the role of the kynurenine pathway in multiple system atrophy
RN
Ryunosuke Nagao
Fujita Health University
KK
Kazuya Kawabata
Fujita Health University
SS
Sayuri Shima
Fujita Health University
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Key Points
Altered tryptophan metabolism correlates with neurodegeneration in multiple system atrophy.
Key evidence includes observed levels of kynurenine metabolites indicating disease severity.
Observational analysis investigates metabolic pathways using biological samples from affected individuals.
Findings support identifying potential biomarkers, though further studies are necessary to confirm results.
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Nagao et al. (Mon,) studied this question.
synapsesocial.com/papers/69a75f0ec6e9836116a2a2af
https://doi.org/https://doi.org/10.1016/j.jns.2025.125291