MONNA alleviates MPTP-induced Parkinson’s disease in zebrafish by activating TFEB dependently on ER Calcium

Key Points

• MONNA reduces symptoms associated with MPTP-induced Parkinson's disease in zebrafish, implying its therapeutic potential.
• Observed improvements are linked to the activation of the TFEB pathway and modulation of ER calcium levels.
• Analysis involves zebrafish models exposed to MPTP, assessing recovery via calcium signaling mechanisms.
• Findings suggest important roles for calcium signaling pathways in Parkinson’s disease treatment strategies.