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March 3, 2026
Rosmarinic Acid Alleviates Ischemic Stroke by Targeting BAG3 to Modulate Autophagy via the P62-Keap1-Nrf2 Pathway
CL
Changli Liu
South China Agricultural University
DL
Dandan Liu
University of Nebraska–Lincoln
PG
Peng Gao
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Key Points
Rosmarinic acid alleviates ischemic stroke by targeting BAG3 to modulate autophagy, enhancing recovery.
The study reveals a significant reduction in neurological deficits following treatment with rosmarinic acid.
Utilizing the p62-Keap1-Nrf2 pathway shows how rosmarinic acid influences autophagy processes.
This approach highlights the potential of rosmarinic acid as a therapeutic agent for ischemic stroke treatment.
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Liu et al. (Thu,) studied this question.
synapsesocial.com/papers/69a75f37c6e9836116a2a6b8
https://doi.org/https://doi.org/10.1016/j.phymed.2026.157904
Rosmarinic Acid Alleviates Ischemic Stroke by Targeting BAG3 to Modulate Autophagy via the P62-Keap1-Nrf2 Pathway | Synapse