Design and computational evaluation of a cross-protective multi-epitope vaccine candidate against Bartonella henselae and Bartonella clarridgeiae pathogens causing the zoonotic cat scratch disease in humans

Key Points

• The vaccine candidate shows cross-protection against two Bartonella pathogens, highlighting its potential for zoonotic disease mitigation.
• Data indicates a significant immune response elicited by the multi-epitope vaccine, with favorable profiles for both Bartonella henselae and Bartonella clarridgeiae.
• Computational evaluation employs advanced modeling techniques to predict immune interactions, enhancing vaccine design and efficacy assessments.
• Further validation in clinical settings is necessary to confirm cross-protective capabilities of the vaccine for broader zoonotic applications.