Baohuoside I induces GSDME-dependent pyroptosis and synergistically inhibits lung adenocarcinoma with cisplatin

Key Points

• GSDME-dependent pyroptosis enhances the effects of cisplatin in lung adenocarcinoma cells.
• Baohuoside I significantly increases cell death when combined with cisplatin, indicating a strong synergy.
• The analysis demonstrates that Baohuoside I promotes pyroptosis through a specific cellular pathway.
• These findings highlight a potential dual-target treatment for lung adenocarcinoma using Baohuoside I and cisplatin.