March 3, 2026Open Access

Ketogenic dietary interventions for autosomal-dominant polycystic kidney disease (ADPKD): a systematic review and synthesis without meta-analysis (SWiM) of observational and interventional studies

Key Points

Caloric-restriction diets may support metabolic feasibility in managing autosomal-dominant polycystic kidney disease.
No consistent evidence shows that ketogenic dietary interventions alter renal structural outcomes.
Systematic analysis encompasses both observational and interventional studies assessing ketogenic dietary interventions.
Longer trials with appropriate comparators like standard care diets are essential to clarify benefits.

Abstract

The evidence on KDIs for ADPKD is still limited. However, KDIs, particularly caloric-restriction diets, appear promising tools for managing ADPKD. Current human data support metabolic feasibility more consistently than renal disease modification. The effects of KDIs on renal structural outcomes remain uncertain and longer trials with appropriate comparators, namely the standard of care diet for ADPKD, are required before KDIs can be recommended for ADPKD.

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Cite This Study

Grammatikopoulou et al. (Sat,) studied this question.

synapsesocial.com/papers/69a75f65c6e9836116a2abe9 https://doi.org/https://doi.org/10.1016/j.metop.2026.100447

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