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March 3, 2026
Neutrophil extracellular traps enhance platinum resistance in ovarian cancer via SHP-1 activation
QZ
Qian Zhao
Sun Yat-sen University
YY
Yao Yao
Guangdong Food and Drug Vocational College
TL
Ting Liang
Sun Yat-sen University
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Key Points
Neutrophil extracellular traps were found to enhance platinum resistance in ovarian cancer cells, leading to treatment difficulties.
The study indicates that SHP-1 activation is a critical mediator in the resistance mechanism, showing a link to tumor survival.
Assessment of patient samples displayed a significant association between increased neutrophil extracellular traps and reduced treatment efficacy.
These findings highlight the potential for targeting SHP-1 pathways in improving treatment strategies for ovarian cancer.
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Neutrophil extracellular traps enhance platinum resistance in ovarian cancer via SHP-1 activation | Synapse
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Zhao et al. (Fri,) studied this question.
synapsesocial.com/papers/69a75f8ac6e9836116a2afc7
https://doi.org/https://doi.org/10.1016/j.canlet.2026.218288