Predicting Brain Amyloid PET Positivity Using the Amyloid Beta Composite (ABC) Index in Patients With Cognitive Impairment

Key Points

• ABC index effectively predicts cerebral amyloid deposition, enhancing patient management.
• Utilizing routine clinical data, the ABC index reduces unnecessary amyloid PET imaging by streamlining selection processes.
• Assessment using the ABC index facilitates targeted anti-amyloid therapies and clinical trial participation; broader implications may follow.
• Enhanced predictive capability may improve patient outcomes while conserving healthcare resources.