Reactive oxygen species-responsive Pluronic F127 hyaluronic hydrogel for targeted doxorubicin delivery in glioblastoma and enhanced survival with radiotherapy

Key Points

• Survival rates improved significantly with the combined treatment of doxorubicin and radiotherapy.
• The use of pluronic F127 hydrogel enabled targeted doxorubicin delivery in glioblastoma models.
• Assessment utilized reactive oxygen species responsiveness to enhance drug delivery effectiveness.
• These findings highlight the potential to improve glioblastoma treatment strategies, though further validation is required.