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Anakinra Prophylaxis during BCMA-Directed CAR-T Therapy: A Two-Center Analysis of Toxicity and Outcomes | Synapse
March 3, 2026
Anakinra Prophylaxis during BCMA-Directed CAR-T Therapy: A Two-Center Analysis of Toxicity and Outcomes
JK
Joshua Kassner
Cornell University
TA
Theresia Akhlaghi
Cornell University
DJ
David Jayabalan
Cornell University
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Key Points
Anakinra prophylaxis reduces toxicity associated with bcma-directed car-t therapy in patients, improving their overall outcomes.
Key findings indicate that the use of anakinra led to a significant decrease in severe adverse effects, enhancing treatment tolerability.
Analytical approach involved a two-center assessment, monitoring the efficacy and safety profiles during car-t therapy.
Findings highlight the need for further exploration of anakinra in preventing toxicities in broader clinical settings.
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Kassner et al. (Sun,) studied this question.
synapsesocial.com/papers/69a7600ec6e9836116a2c774
https://doi.org/https://doi.org/10.1016/j.jtct.2025.12.232
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