Overexpression of IL-8 augments the susceptibility to a hyperinflammatory phenotype in pediatric acute respiratory distress syndrome and correlates with adverse outcomes: a retrospective two-center study conducted in northwest China

Key Points

• Overexpression of IL-8 correlates with increased susceptibility to a hyperinflammatory phenotype in ARDS.
• Infants and young children with ARDS may experience poorer outcomes due to elevated IL-8 levels found alongside RAGE, Ang-2, ICAM-1, and SP-D.
• Retrospective two-center analysis conducted in northwest China highlights clinical implications of IL-8 in pediatric ARDS cases.
• Elevated IL-8 levels may signal a need for targeted interventions in treating hyperinflammatory responses in affected children.