Adipokine CTRP12 Alleviates Experimental Colitis by Participating in Modulating Mesenteric M2 Macrophage Polarization in IL-10 KO Mice
Key Points
CTRP12 alleviates colitis symptoms by modulating macrophage polarization toward the M2 type, enhancing recovery.
The study shows CTRP12's role in macrophage function, with significant effects observed in IL-10 knockout mice.
Observational analysis identified how CTRP12 influences macrophage behavior and inflammatory responses in colitis models.
This work highlights new avenues for therapeutic strategies targeting macrophage polarization in Crohn's disease.
Abstract
These findings suggest adipokine CTRP12 could ameliorate Crohn's colitis by modulating polarization of mesenteric macrophages to M2 type, providing new target for Crohn's disease therapy.
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Adipokine CTRP12 Alleviates Experimental Colitis by Participating in Modulating Mesenteric M2 Macrophage Polarization in IL-10 KO Mice | Synapse