March 3, 2026Open Access

Why have extracorporeal carbon dioxide removal clinical trials failed?

Key Points

Current evidence does not support extracorporeal carbon dioxide removal for routine clinical use, highlighting its challenges.
Despite theoretical advantages, potential complications reduce the effectiveness of ECCO2R interventions.
Trial outcomes lack significant benefit, indicating a disconnect between expected and observed results in patients.
Complications from ECCO2R procedures necessitate careful consideration before approaching clinical application.

Abstract

INTRODUCTION Extracorporeal carbon dioxide removal (ECCO2R) is designed to eliminate carbon dioxide (CO2) from the blood.() Despite its theoretical advantages, current evidence does not support its routine clinical use outside of clinical trials, due to possible complications and the lack of benefit in the latest clinical trial.() From this viewpoint, we discuss possible reasons why …

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Cite This Study

Santos et al. (Thu,) studied this question.

synapsesocial.com/papers/69a76017c6e9836116a2c844 https://doi.org/https://doi.org/10.62675/2965-2774.20260266

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