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Allogeneic Transplant Outcomes in Adults Aged ≥75 Receiving Fludarabine/Melphalan Conditioning and Post-Transplant Cyclophosphamide | Synapse
March 3, 2026
Allogeneic Transplant Outcomes in Adults Aged ≥75 Receiving Fludarabine/Melphalan Conditioning and Post-Transplant Cyclophosphamide
HC
Howard Y. Chang
Amgen (United States)
SW
Staci Williamson
Oregon Health & Science University
DC
Daniel Chandra
Oregon Health & Science University
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Key Points
Transplant outcomes are improved with the use of fludarabine and melphalan conditioning in older adults.
Key evidence reveals the effectiveness of cyclophosphamide as a post-transplant intervention.
Assessment using allogeneic transplant outcomes highlights the feasibility in a previously underrepresented age group.
Adverse effects may occur, indicating the need for careful monitoring in elderly patients.
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Chang et al. (Sun,) studied this question.
synapsesocial.com/papers/69a7602cc6e9836116a2ca98
https://doi.org/https://doi.org/10.1016/j.jtct.2025.12.683
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