March 3, 2026SHILAP Revista de lepidopterología0 citationsOpen Access

Nonlinear association between hematocrit and 3-month outcome after acute ischemic stroke: identification of threshold effects in males

XLXiaomin LiangShenzhen Second People's Hospital QWQian WangChinese University of Hong Kong, Shenzhen ZXZemao XingShenzhen Second People's Hospital

Key Points

Adverse outcomes increase with low hematocrit in males after acute ischemic stroke, indicating a potential threshold effect.
In males, hematocrit levels below a specific value show a significant link to worse 3-month outcomes.
The analysis focused on the nonlinear relationship, revealing different outcomes based on sex in acute ischemic stroke patients.
Findings underscore the importance of considering sex differences in treatment and management strategies for stroke patients.

Abstract

This study revealed a nonlinear, sex-specific relationship between HCT and 3-month outcome in AIS patients. In male patients, HCT levels below the threshold were inversely associated with adverse outcome, while no significant association was observed in female patients.

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