Rebound Phenomenon of Platelet Reactivity After Cessation of Long-Term Clopidogrel Therapy

Key Points

• Heightened platelet reactivity occurs after cessation of long-term clopidogrel therapy, increasing thrombotic risk.
• A significant rebound in platelet activity is observed within a month of therapy discontinuation.
• Assessment using platelet aggregation tests reveals variability in individual responses to cessation.
• Findings imply the need for careful management of antiplatelet therapy during treatment transitions.