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An enigmatic case of primary refractory myeloma: Mystery solved | Synapse
March 3, 2026
Open Access
An enigmatic case of primary refractory myeloma: Mystery solved
KM
Kumar Nikhil M
Fortis Memorial Research Institute
NS
Nathany Shrinidhi
Fortis Memorial Research Institute
SA
Sebastian Anusha
Fortis Memorial Research Institute
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Key Points
Primary refractory myeloma demonstrates unresolved therapy resistance, complicating effective treatment options.
Key biomarker analysis identified significant genetic mutations associated with therapy resistance in this case.
Assessment using advanced genetic profiling revealed distinct molecular pathways contributing to refractory myeloma.
Understanding these pathways may enable targeted therapies, improving outcomes for similar cases in the future.
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M et al. (Tue,) studied this question.
synapsesocial.com/papers/69a760c5c6e9836116a2dd48
https://doi.org/https://doi.org/10.1016/j.cpccr.2026.100408