PRDX6 as a Ferroptosis-Related Hub Gene in the Entorhinal Cortex of Alzheimer’s Disease: A Multidimensional Bioinformatics and Experimental Validation Study

Key Points

• PRDX6 plays a crucial role in ferroptosis within the entorhinal cortex, impacting Alzheimer's pathology.
• Bioinformatics analysis revealed significant expression changes in PRDX6 in Alzheimer's-affected brain regions.
• Experimental validation confirmed the involvement of PRDX6 in cellular mechanisms related to neuronal health.
• Understanding PRDX6's role may help in developing targeted therapies for Alzheimer's disease.