Systematic profiling of SARS-CoV-2 structural protein-specific T cell epitopes in Omicron infections following inactivated vaccination

Key Points

• Inactivated vaccination improves the immune response to SARS-CoV-2 variants, particularly Omicron.
• Significant T cell epitopes were identified, linking adaptive immunity to specific structural proteins.
• Observational analysis reveals the relationship between vaccination and T cell responses post-infection with Omicron.
• Findings highlight the potential for better vaccine designs targeting specific epitopes for future variants.