Does the combination of early bone marrow-derived mesenchymal stem cell transplantation and endurance training improve exercise-induced ventricular ectopy, myocardial infarction-induced injury, and cardiac function in a rat model of myocardial infarction?
This preclinical study protocol evaluates the synergistic effects of BM-MSC transplantation and endurance training on post-MI recovery in rats, though results are not available in the truncated text.
This study investigated the synergistic effect of early bone marrow-derived mesenchymal stem cells (BM-MSC) transplantation and endurance training on exercise-induced ventricular ectopy, myocardial infarction-induced injury and cardiac function in rats. 90 male Wistar rats (7-8 weeks) randomly distributed following groups, 1: Healthy control (HC, n = 15), 2: Sham (Sham, n = 15), 3 Myocardial infarction (MI, n = 15), 4: Myocardial infarction with BM-MSC transplantation (MI-SC, n = 15), 5: Myocardial infarction with Endurance training (MI-ET, n = 15) and 6: Myocardial infarction with Endurance training and BM-MSC transplantation (MI-ET + SC, n = 15). Myocardial infarction was induced by permanent obstruction of the cardiac left anterior descending artery. One day after MI induction, 1 × 10
Abazari et al. (Sat,) studied this question.