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Molecular mechanisms in endometriosis: linking JAK/STAT pathway, ferroptosis, and microbial dysbiosis | Synapse
March 3, 2026
Molecular mechanisms in endometriosis: linking JAK/STAT pathway, ferroptosis, and microbial dysbiosis
HS
Humaira Shah
University of Malaya
NS
Naguib Salleh
MH
Mukhri Hamdan
University of Malaya
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Key Points
JAK/STAT pathway interactions significantly influence ferroptosis in endometriosis, impacting disease progression.
The study finds elevated levels of specific cytokines related to oxidative stress in endometriosis.
Analysis highlights the role of microbial dysbiosis in exacerbating endometriosis symptoms and inflammation.
Understanding these mechanisms may enable targeted therapies for managing endometriosis effectively.
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Shah et al. (Sat,) studied this question.
synapsesocial.com/papers/69a76163c6e9836116a2f444
https://doi.org/https://doi.org/10.1007/s11033-025-11401-6