Two-Pronged Specialist (TPS) probe: an ultra-sensitive enzyme-driven universal system for dual-microRNA detection

Key Points

• Enhanced sensitivity for microRNA detection significantly improves diagnostic capabilities, and can detect multiple targets simultaneously.
• Detection achieved sensitivity levels 100 times higher than conventional methods, promoting its clinical relevance.
• Assessment using an enzyme-driven dual-microRNA probe demonstrates substantial advances in detection technology.
• This work highlights the potential to improve diagnostic accuracy in clinical settings, driven by enzyme-linked methods.