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Research Paper | Synapse
March 3, 2026
PINK1 deacetylation by emodin-induced SIRT3 upregulation alleviates acute kidney injury by Inhibition of ferroptosis
RW
Rui Wang
Hubei University of Chinese Medicine
ZZ
Ziwei Zou
Hubei University of Chinese Medicine
YA
Yi An
Wuhan University of Technology
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Key Points
Acute kidney injury is alleviated, highlighting the role of SIRT3 in mitigating ferroptosis.
SIRT3 upregulation through emodin positively impacts PINK1 deacetylation.
Inhibition of ferroptosis provides a protective effect on kidney cells during injury periods.
Further exploration of this pathway could lead to new therapies for treating acute kidney injury.
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Wang et al. (Tue,) studied this question.
synapsesocial.com/papers/69a761adc6e9836116a2fb87
https://doi.org/https://doi.org/10.1007/s00011-025-02137-x