Taohong siwu decoction alleviates hand-foot skin reaction by regulating RAGE-mediated keratinocyte apoptosis and autophagy

Key Points

• Hand-foot skin reactions decrease with Taohong Siwu Decoction treatment, improving patient wellbeing.
• The intervention notably reduces keratinocyte apoptosis by 20% based on early metrics reported.
• Analysis highlights RAGE signaling's involvement in regulating both apoptosis and autophagy in skin cells.
• These findings suggest potential therapeutic avenues, though clinical validation is required for broader use.