Persistence of residual insulin secretion in long-standing Cystic Fibrosis Related Diabetes

Key Points

• Residual insulin secretion, as measured by C-peptide levels, remains consistent despite longer diabetes duration, contrasting with type 1 diabetes.
• The ratio of proinsulin to C-peptide is lower in cystic fibrosis related diabetes, indicating reduced beta-cell dysfunction compared to type 1 diabetes.
• This analysis involved a cohort of individuals with cystic fibrosis related diabetes, examining their fasting and stimulated C-peptide levels.
• The findings support a shift towards non-insulin therapies for managing diabetes in adults with cystic fibrosis, highlighting a need for alternative treatment strategies.

Abstract