The RNA-binding protein Imp1 promotes a Spdef transcriptional program and mucus fucosylation during necrotizing enterocolitis

Key Points

• Imp1 upregulation significantly enhances goblet cell maturation and mucus fucosylation during necrotizing enterocolitis (NEC).
• Increased activity of Spdef plays a key role in promoting improved goblet cell function in the context of NEC.
• Analysis involved assessing the biological functions of Imp1 in relation to Spdef within NEC pathology.
• Findings highlight the importance of the Imp1-Spdef pathway in mucus production, suggesting targets for NEC interventions.