3-Deoxyanthocyanidins inhibit β-amyloid aggregation, toxicity, and mitochondrial dysfunction: Evidence from MC-65 cells and molecular dynamics simulations

Key Points

• 3-deoxyanthocyanidins significantly inhibit beta-amyloid aggregation and resulting toxicity, showcasing their protective potential.
• In MC-65 cells, treatment with 3-deoxyanthocyanidins reduced mitochondrial dysfunction linked to beta-amyloid toxicity.
• Molecular dynamics simulations indicate structural stability and interaction efficacy of 3-deoxyanthocyanidins with beta-amyloid.
• Findings suggest that 3-deoxyanthocyanidins may be developed as a therapeutic option against neurodegenerative disorders.