Neural – adipose crosstalk: Shared genetic architecture of visceral fat and neuropsychiatric disorders | Synapse
March 3, 2026Open Access
Neural – adipose crosstalk: Shared genetic architecture of visceral fat and neuropsychiatric disorders
Key Points
Shared genetic framework highlights the connection between neuropsychiatric disorders and visceral fat.
The crosstalk centers on hypothalamic-synaptic mechanisms, showing important interactions.
Therapeutic targets may be identified through understanding these genetic links, enhancing treatment options.
These findings underscore the importance of considering metabolic health in neuropsychiatric contexts.
Abstract
These findings support a shared genetic framework for brain-adipose crosstalk centered on hypothalamic-synaptic mechanisms and highlight potential therapeutic targets for comorbid management.