March 3, 2026Journal of Visualized Experiments0 citations

Real-Time Imaging of Bacterial Infection in a Mouse Model Using Bioluminescence

Key Points

Real-time imaging shows infection spread in a mouse model, enhancing understanding of bacterial dynamics.
Key evidence reveals that bioluminescence can effectively visualize infection sites during progression.
Assessment using bioluminescence and X-ray imaging methods allows for detailed anatomical localization.
Highlighting the potential to improve infection monitoring and therapeutic interventions in clinical settings.

Abstract

Source: Valentine, M. E., et al., Generation of In-Frame Gene Deletion Mutants in Pseudomonas aeruginosa and Testing for Virulence Attenuation in a Simple Mouse Model of Infection. J. Vis. Exp. (2020)This video demonstrates the use of a bioluminescence-based imaging approach to monitor bacterial infection in a live mouse model. Sequential bioluminescent and X-ray imaging enables real-time visualization and anatomical localization of infection spread throughout the host.

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