Prognostic and recurrence implications of subdividing WHO grade 2 pancreatic neuroendocrine tumors at a 10% Ki-67 threshold

Key Points

• The study finds that tumors with a Ki-67 threshold of 10% can better predict recurrence risk.
• Specifically, tumors beneath this threshold had recurrence rates lower than those above it, emphasizing prognostic relevance.
• Analysis across multiple institutions highlights the need for consistent grading criteria for tumor stratification.
• These findings may enhance treatment planning but require validation across larger, diverse cohorts.