Global lysine 2-hydroxyisobutyrylation profiling reveals the growth mechanism of Lactobacillus paracasei PC-01 in high-density cultures

Key Points

• Lysine 2-hydroxyisobutyrylation regulates growth mechanisms in Lactobacillus paracasei, demonstrating key metabolic insights.
• Analysis revealed specific metabolic pathways that support Lactobacillus paracasei growth under high-density culture conditions.
• Comprehensive profiling identified pivotal biochemical modifications influencing bacterial growth dynamics through lysine modifications.
• Implications highlight potential for optimized fermentation strategies, enhancing industrial applications of Lactobacillus species.