March 3, 2026Open Access

Gamma tACS as a novel treatment for primary progressive aphasia: A pilot case series of four cases

Key Points

Temporal improvement in cognitive function observed with gamma-frequency stimulation over the precuneus, highlighting its potential.
In a pilot case series, four patients with primary progressive aphasia responded positively to gamma tACS intervention.
Transcranial alternating current stimulation was applied to induce gamma oscillations, potentially improving cholinergic system function.
Further investigation needed to assess the broader implications and efficacy of gamma tACS in varied populations.

Abstract

A recent study found that applying gamma-frequency (40 Hz) transcranial alternating current stimulation (γ-tACS) over the precuneus in Alzheimer’s disease (AD) patients temporarily improved the patients’ episodic memory and function of the cholinergic system.1 γ-tACS incites physiological gamma oscillations in cortical neurons with disturbed or decreased high-frequency oscillatory activity.2 First noted by Assogna et al.3, the cellular death of cortical GABAergic interneurons has been observed in a TARDBP-overexpressing mouse model of frontotemporal dementia (FTD) which might result in a decrease in gamma-frequency oscillations due to the loss of inhibitory control by interneurons.

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Cite This Study

Etelämäki et al. (Mon,) studied this question.

synapsesocial.com/papers/69a76623badf0bb9e87dbd4b https://doi.org/https://doi.org/10.1016/j.brs.2026.103046

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