March 3, 2026Open Access

Postoperative Radiotherapy May Improve Survival in Certain Patients with pN2 Non-Small Cell Lung Cancer Who Do Not Have Extranodal Extension

Key Points

Postoperative radiotherapy significantly reduces local regional recurrence in specific patients, emphasizing targeted treatment.
In subgroup analyses, patients with limited nodal burden and those without extranodal extension show potential survival benefits.
Retrospective design assessed overall survival and disease-free survival across various patient profiles but lacked improvement in the matched cohort.
This highlights the need for careful interpretation, as small subgroup sizes may affect the robustness of the findings.

Abstract

Although PORT did not improve OS or DFS in the matched overall cohort, it significantly reduced LRR. Subgroup analyses suggested potential benefits in patients with limited nodal burden and in those without ENE or lymphatic invasion. These findings, however, should be interpreted cautiously given small subgroup sizes and inherent limitations of retrospective design.

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Cite This Study

Jeon et al. (Tue,) studied this question.

synapsesocial.com/papers/69a76623badf0bb9e87dbd77 https://doi.org/https://doi.org/10.4143/crt.2025.644

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