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March 3, 2026
Epigenetic and MicroRNA signatures as predictive biomarkers in HCV genotype 4-Induced liver cirrhosis and HCC
RE
Rady E. El-Araby
Tufts University
MK
Mahmoud A. Khalifa
MZ
Mona M. Zoheiry
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Key Points
Liver cirrhosis is predicated by specific epigenetic changes and microRNA signatures, indicating a link to HCC.
Notable biomarkers were observed, with 75% of patients exhibiting alterations related to liver cancer risk.
Analysis included case records from patients diagnosed with hepatitis C virus genotype 4, revealing critical epigenetic patterns.
Findings highlight a need for broader studies to validate biomarkers in diverse populations with liver disease.
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Epigenetic and MicroRNA signatures as predictive biomarkers in HCV genotype 4-Induced liver cirrhosis and HCC | Synapse
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El-Araby et al. (Mon,) studied this question.
synapsesocial.com/papers/69a76663badf0bb9e87dcd19
https://doi.org/https://doi.org/10.1007/s11033-025-11323-3