Homocysteine as a Dual Vasculo-Metabolic Risk Factor for Cognitive Impairment Specific to the Indian Context: A Systematic Review and Meta-Analysis

Key Points

• Cognitive impairment is significantly associated with elevated homocysteine levels, suggesting an increased risk.
• In the analysis, participants showed varying degrees of cognitive decline correlated with homocysteine variability.
• Systematic review and meta-analysis were employed to investigate the relationship between homocysteine and cognitive impairment.
• Findings highlight the importance of addressing homocysteine levels in preventing cognitive decline among Indian populations.