Mechanistic insights into amyloid β fibril disruption by ginsenosides through molecular dynamics simulations

Key Points

• Disruption of amyloid beta fibrils is significantly enhanced by ginsenosides, demonstrating efficacy in structural reconfiguration.
• Molecular dynamics simulations showed that ginsenosides induce conformational changes in amyloid structures.
• The interaction dynamics highlight the role of ginsenosides in targeting specific molecular pathways related to amyloid pathology.
• These findings suggest further research is needed to explore ginsenosides' therapeutic applications, offering hope for neurodegenerative treatments.