The impact of NUDT15 p.R139H on thiopurine tolerance in children with acute lymphoblastic leukemia.

Key Points

• Thiopurine tolerance was significantly affected by NUDT15 p.R139H variant; children demonstrated varied responses to treatment.
• The presence of the NUDT15 p.R139H variant correlated with a higher incidence of adverse drug reactions in pediatric patients.
• Observational analysis focused on children with acute lymphoblastic leukemia to ascertain genetic effects on thiopurine intolerance.
• Further investigation into genetic biomarkers like NUDT15 may help personalize treatment plans for better outcomes.