Export Brucellosis, a globally significant zoonosis, demands rapid, accurate diagnostics to optimize therapeutic intervention and containment. Traditional detection methods face critical limitations, including poor discrimination between acute and past infections and lengthy testing times. In recent years, detection technologies based on surface-enhanced Raman scattering (SERs) have emerged as a focal point in the field of Brucella diagnosis, offering high sensitivity, real-time readouts, and portability. This review highlights pioneering SERS applications, particularly its synergy with lateral flow immunochromatography, detailing their mechanistic basis, diagnostic metrics, and clinical translational prospects. In addition, we further discuss the advantages and current limitations of SERS technology in disease staging, rapid screening, and deployment in resource-limited settings, drawing on the latest research findings to provide theoretical support and practical guidance for the advancement of Brucella detection methods.
Yang et al. (Thu,) studied this question.