Ameliorative Potential of Desmodium adscendens Leave (EDAL) Extract on Blood Parameters in Phenylhydrazine-induced Anaemic Rats

Medicinal plants, when regulated and used correctly can help to prevent and treat a variety of health conditions. We investigated the ameliorative potential of Desmodium adscendens leave (EDAL) extract on blood parameters in phenylhydrazine induced anaemic rats. Twenty-five (25) male albino Wistar rats weighing 180-200g, were randomly assigned to 5 groups of five rats each. Group1(normal control), Group 2 (anaemic control) was challenged with phenylhydrazine (60mg/kg, B.W., intraperitoneal) without treatment. Group 3 received EDAL orally at 150mg/kg, B.W., Group 4 and 5 were challenged with phenylhydrazine (60mg/kg, B.W,) and treated orally with 150mg/kg and 300mg/kg of extract of Desmodium adscendens leaves (EDAL) respectively. All animals were allowed free access to food and water pre and post treatment for 14 days. At the end of the treatment period, the animals were euthanized, and blood samples collected via cardiac puncture for biochemical analysis. The results showed that there was significant (P<0.05) decrease in most haematological indices except MCV, MCH, total white blood cell and neutrophils which recorded a significant (p<0.05) increase in anaemic control compared with normal control and extract group. Treatment with extract reverses these indices to almost similar level compared with control. Our findings suggest that the extract of Desmondium adscendens leaves has the capacity to ameliorates the Phenylhydrazine-induced haematotoxicity by reversing oxidative imbalances due to its phytochemical composition.