March 3, 2026Open Access

Systemic immune-inflammation index as a novel biomarker for predicting surgical site infection in people living with HIV: a multicenter, retrospective cohort study

Key Points

Systemic immune-inflammation index (SII) predicts surgical site infection effectively in HIV-positive individuals, enhancing clinical care.
The SII exhibits potential as a cost-effective biomarker, distinguishing patients at high risk for surgical complications.
Retrospective cohort analysis conducted across multiple centers validated the SII's effectiveness for risk stratification.
Incorporating SII assessments may optimize perioperative management for surgical patients living with HIV.

Abstract

The SII may serve as a clinically accessible and cost-effective biomarker for identifying HIV-infected patients at increased risk of SSI. Incorporating preoperative SII assessment could support perioperative risk stratification and management. This novel approach has implications for optimizing patient care for HIV-positive surgical populations.

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Cite This Study

Gong et al. (Fri,) studied this question.

synapsesocial.com/papers/69a76746badf0bb9e87e03f7 https://doi.org/https://doi.org/10.3389/fcimb.2026.1529202

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