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Strategic engineering of imidazopyridine-benzoxazole hybrids targeting microtubule dynamics: comprehensive inhibition of the metastatic cascade | Synapse
March 3, 2026
Strategic engineering of imidazopyridine-benzoxazole hybrids targeting microtubule dynamics: comprehensive inhibition of the metastatic cascade
BK
Burak Kuzu
Van Yüzüncü Yıl Üniversitesi
MÇ
Mustafa Çakır
EA
Eda Açıkgöz
Key Points
Comprehensive inhibition of the metastatic cascade is achieved through engineered hybrids targeting microtubule dynamics.
Key evidence includes significant interference with microtubule organization and cancer cell migration due to specific hybrid interactions.
The approach involved strategic engineering of imidazopyridine-benzoxazole hybrids to examine their effects on microtubule dynamics.
These findings highlight the potential for developing novel therapies targeting microtubule dynamics to combat cancer metastasis.
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Kuzu et al. (Thu,) studied this question.
synapsesocial.com/papers/69a76769badf0bb9e87e0d06
https://doi.org/https://doi.org/10.1016/j.bioorg.2026.109615
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