Unmasking hypoxia's double-edged sword: Mechanistic insights into granulosa cell adaptation and dysfunction

Key Points

• Granulosa cell dysfunction occurs under hypoxic conditions, leading to impaired ovarian function.
• Key evidence shows that hypoxia influences cellular responses in granulosa cells, affecting their survival and function.
• Observational analysis explores the mechanistic pathways of granulosa cells under varying oxygen levels, detailing both adaptation and dysfunction.
• Understanding hypoxia's dual role may enable better therapeutic strategies for reproductive health issues.