Pt(II) and Pd(II) complexes bearing 1,10-phenanthroline-based ligands: Distinct binding modes to DNA and anticancer activities

Key Points

• Distinct binding modes of Pt(II) and Pd(II) complexes to DNA were observed, revealing unique interactions with the genetic material.
• Anticancer activities were demonstrated, with specific efficacy profiles differing between Pt(II) and Pd(II) complexes.
• The study employed in vitro assays to assess the interaction of these complexes with DNA, highlighting their potential in cancer therapy.
• Findings suggest these metal complexes might serve as frameworks for developing new anticancer drugs, inviting further exploration.